解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
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产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
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运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
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健康政策和服务
心理学,临床
abstract::The relationship of plasma glucose levels to risk of death over a five-year follow-up period was studied in 2,770 male survivors of myocardial infarction in the placebo group of the Coronary Drug Project (CDP). In univariate analyses, a positive association was observed between mortality rates and both fasting and one...
journal_title:Diabetes
pub_type: 临床试验,杂志文章
doi:
更新日期:1977-05-01 00:00:00
abstract::A 21-year-old female patient complaining of frequent hypoglycemic attacks in the presence of a large amount of circulating insulin-binding antibodies without previous known immunization is described. In order to clarify the possible mechanism of the hypoglycemic attacks occurring in this new syndrome, changes in plasm...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.26.5.500
更新日期:1977-05-01 00:00:00
abstract::Studies in 10 nonketotic diabetic subjects (five juvenile- and five adult-onset) before and after control of carbohydrate metabolism showed a high degree of correlation between hemoglobin AIc (HbAIc) concentrations and serum triglyceride levels. Serum triglyceride levels were found to correlate more closely with Hb AI...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.26.5.507
更新日期:1977-05-01 00:00:00
abstract::Two similar intravenous infucion techniques have been utilized to investigate insulin sensitivity in young subjects with recent-onset ketosis-prone diabetes mellitus. All subjects presented initially with mild to moderately severe ketoacidosis and had been treated with daily insulin therapy for two to eight weeks at t...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.26.4.278
更新日期:1977-04-01 00:00:00
abstract::To treat insulin lipoatrophy, small amounts of dexamethasone (4 micrograms/unit) were added to insulin injections in nine patients. Six cases showed significant improvement of dexamethasone-treated sites over that of control sites in six months. With the continued use of dexamethasone-containing insulin, they remained...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.26.4.296
更新日期:1977-04-01 00:00:00
abstract::The data being reported are part of an epidemiologic study of health and disease in an entire community, Tecumseh, Michigan. Approximately 1,300 males age 16-65 were classified into three groups on the basis of their habitual leisure and occupational physical activity. A blood sample was drawn one hour after a glucose...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.26.3.172
更新日期:1977-03-01 00:00:00
abstract::Isologous pancreatic islets were implanted into the portal vein of rats with streptozotocin-induced diabetes. At intervals of from one to 32 days after transplantation, the intrahepatic islet grafts were examined histologically and ultrastructurally, and their vascular supply was determined by later perfusion studies....
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.26.3.201
更新日期:1977-03-01 00:00:00
abstract::The Diabetes Association of greater Cleveland screened 307,000 individuals in the metropolitan area for diabetes with a 75-gm. oral load of carbohydrate. Of these subjects 12,600 (4.1 per cent) had a two-capillary blood glucose level of greater than 139 mg. per cent and were defined as positive. Seventy per cent of th...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.25.12.1110
更新日期:1976-12-01 00:00:00
abstract::During epidemiologic investigations of vascular complications of diabetes in Warsaw the habit of cigarette smoking was analyzed in the subjects studied (4,530 diabetics). It was found that in the group of diabetics the number of ex-smokers was much greater (p less than 0.01) and that of present smokers lower (p less t...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.25.8.717
更新日期:1976-08-01 00:00:00
abstract::Toxin from the scorpion Leiurus quinquestriatus was used to release norepinephrine from sympathetic nerve endings in the perfused rat pancrease. Addition of toxin, 10 mug./ml., to perfusate containing 0.3 mg./ml. glucose caused a large increase in release of norepinephrine and glucagon. Glucagon secretion was suppress...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.25.8.645
更新日期:1976-08-01 00:00:00
abstract::In order to study hyperlipidemia in diabetes mellitus, rats were made diabetic by administration of streptozotocin and the optimal conditions for production of severe and persistent hyperlipoprotenemia determined. Two groups of rats were compared: rats fed sucrose-rich diets and rats fed laboratory chow. The optimal d...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.25.6.509
更新日期:1976-06-01 00:00:00
abstract::Studies have been carried out on activities of lysosomal beta-N-acetylhexosaminidase (hex), beta-galactosidase (beta-gal), alpha-glucosidase (alpha-glu), and acid phosphatase (AP) in serum and urine from patients with juvenile diabetes and matched controls. There is a large increase in blood and urinary hex activity (...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.25.5.420
更新日期:1976-05-01 00:00:00
abstract::Fasting hypoglycemia occurred in a patient with a histologically benign mesothelioma; the serum insulin was low (2-4 muU./ml.), as was the glucose utilization rate. Splanchnic glucose output was markedly decreased on direct measurement (21 mg./min.; normal: 108-180 mg./min.). Splanchnic uptake of gluconeogenic substra...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.25.3.202
更新日期:1976-03-01 00:00:00
abstract::Diabetic microangiopathy is a slowly progressive condition that usually manifests itself years after the onset of the carbohydrate-metabolism disturbance. It is a far more striking problem in some diabetics than in others. Differences in the pattern of its effect in several body systems suggest that the local vascular...
journal_title:Diabetes
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
abstract::The minor hemoglobins AIa, AIb, and AIc were studied in mice with either genetic or chemically induced diabetes. Hemoglobin AIc was elevated approximately twofold in all the phenotypically diabetic mice studied (C57BL/KsJ-db/db, C57BL/KsJ-ob/ob, C57BL/6J-db/db, and alloxan- and streptozotocin-treated mice). Elevation ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.25.1.1
更新日期:1976-01-01 00:00:00
abstract::The isolated rat liver perfused for 12 hours at pH 7.10 with a suspension of bovine erythrocytes in Krebs-Ringer bicarbonate buffer containing 3 per cent bovine serum albumin has been used as a test system to study effects of glucagon and of dexamethasone in the presence and absence of insulin on net biosynthesis of r...
journal_title:Diabetes
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
abstract::Previous studies of diabetic renovascular complications have measured morphologic changes in relatively few glomerular vessels by electron microscopy. The present study samples 20,000 to 80,000 glomeruli from each of ten nondiabetic and ten diabetic age- and sex-matched subjects. Glomeruli were isolated and fractionat...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.24.12.1057
更新日期:1975-12-01 00:00:00
abstract::We present a patient who developed insulin-requiring diabetes several years after the onset of symptoms of anterior hypopituitarism. It is likely that the hypopituitarism protected him against the development of diabetic retinopathy and glomerular basement membrane thickening but not against neuropathy and atheroma. T...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.24.11.1027
更新日期:1975-11-01 00:00:00
abstract::The inhibitory actions of somatostatin (100 ng./ml.) on insulin release, stimulated by high glucose (20 mM), and on glucagon release, stimulated by arginine (15 mM), were studied with two in vitro systems: the isolated perifused rat islets prepared by the collagenase procedure and the isolated perfused rat pancreas. S...
journal_title:Diabetes
pub_type: 历史文章,杂志文章
doi:10.2337/diab.24.11.961
更新日期:1975-11-01 00:00:00
abstract::The effect of cerebral intraventricular insulin on pancreatic insulin secretion was investigated. An extracorporeal pancreatic blood circuit was established after laparotomy to monitor blood flow and insulin concentration directly from the superior pancreaticoduodenal vein. Phentolamine was infused throughout (0.2 mg....
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.24.10.910
更新日期:1975-10-01 00:00:00
abstract::Insulin antagonism characterizes infection, but the mechanism is unknown. Previous studies have been performed during the acute catabolic stage of infection, and the resultant metabolic changes reflect this decreased food intake and weight loss. To delineate metabolic alterations due to infection itself, rats with pye...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.24.10.881
更新日期:1975-10-01 00:00:00
abstract::The effect of muscular exertion of moderate intensity on blood sugar (BS), plasma levels of growth hormone (GH), glucagon, and cortisol (F) has been studied in endocrinologically normal children with short stature and compared with children with clinical diabetes mellitus and obese children with normal and diminished ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.24.8.758
更新日期:1975-08-01 00:00:00
abstract::Fed male Wistar rats were eviscerated by two procedures. The first group of eviscerated rats were left with a nonfunctional liver in situ while the second group were eviscerated by a newer technic, developed in this laboratory, that preserves liver function. The animals were maintained on a regimen of saline and antib...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.24.7.637
更新日期:1975-07-01 00:00:00
abstract::A patient with functioning islet cell carcinoma is described who had amelioration of her hypoglycemia during the development of ectopic ACTH syndrome. Moon facies and hyperkalemic metabolic acidosis were also present in this patient, features uncommonly seen in the actopic ACTH syndrome. At autopsy, she was found to h...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.24.6.600
更新日期:1975-06-01 00:00:00
abstract::Metabolic interactions between glucose and amino acids were studied with isolated rat islets using glucose utilization and lactate formation as indicators. Certain amino acids (8-10 mM) are capable of greatly stimulating lactate formation from 5mM glucose. On a molar basis L-isoleucine is the most potent stimulator in...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.24.5.476
更新日期:1975-05-01 00:00:00
abstract::To evaluate the role of splanchnic and peripheral tissues in the disposal of an oral glucose load, splanchnic exchange of glucose, lactate, pyruvate, glycerol and amino acids was determined in ten healthy subjects in the basal state and for three hours following the oral ingestion of 100 gm. of glucose. Following glu...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.24.5.468
更新日期:1975-05-01 00:00:00
abstract::In vivo studies were undertaken in rats to provide evidence of the neural nature, tentative localization and mode of excitation of the insulin-sensitive central nervous system (CSN) glucoregulator center. In rats under light barbiturate anesthesia minute amounts of insulin injected into the carotid artery resulted in ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.24.4.328
更新日期:1975-04-01 00:00:00
abstract::A double-blind crossover study of fludrocortisone, 0,1 mg. twice daily, and placebo is reported in six diabetics with troublesome symptoms of postural hypotension due to autonomic neuropathy. During treatment with the active preparation there was an increase in the lying and tilted systolic blood pressure, a decrease ...
journal_title:Diabetes
pub_type: 临床试验,杂志文章
doi:10.2337/diab.24.4.381
更新日期:1975-04-01 00:00:00
abstract::The clinical features of the experimental hyperosmolar diabetic (EHD) rat model resemble those seen in the human syndrome--extreme hyperglycemia without ketoacidosis is common to both. The absence of ketoacidosis in the syndrome has been ascribed to both substrate (free fatty acid) deficiency and to interference with ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.24.3.301
更新日期:1975-03-01 00:00:00
abstract::Nonketotic, genetically diabetic Cinese hamsters show subnormal pancreatic insulin release and impaired suppression of glucagon in response to glucose. To study the pancreatic effects of other agents, dynamic insulin and glucagon release was measured from the in vitro perfused pancreases of normal and diabetic Chinese...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.24.3.273
更新日期:1975-03-01 00:00:00
abstract::The responsiveness of the isolated perfused rat liver to different metabolic effects of insulin was investigated during recycling perfusion. Infusion of porcine insulin at rates of 6, 9, 16 and 33 mU/hr. resulted in stable perfusate insulin levels averaging 41, 72, 120 and 229 muU/ml., respectively. Since the portal v...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.24.2.225
更新日期:1975-02-01 00:00:00
abstract::Clinical factors related to the development and progression of renal lesions were studied in twenty-three diabetics by the use of serial renal biopsies or autopsy. The results were as follows: Most of the juvenile and intermediate type diabetics were poorly controlled, with the glomerular lesion progressing rather rap...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.24.1.1
更新日期:1975-01-01 00:00:00